The MilliSolve™ vacuum filtration system has been designed for the filtration of liquid chromatography (LC) buffers and solvents under vacuum. The system uses a 0.45µm membrane filter to eliminate particles which could shorten HPLC column life. Vacuum filtration with the MilliSolve™ HPLC solvent filtration system also removes a large portion of dissolved gases from buffers, which reduces the risk of air bubbles that could interfere with liquid chromatography instruments. With automatic and continuous filtration, there is no need to add liquid into a funnel as filtration progresses. Filtration occurs in a closed system which is an important feature when filtering hazardous and flammable solvents and liquids. If open funnel filtration is required a 300mL funnel replaces the vacuum cover.