The MultiScreen filtering microplate with Ultracel® 10 membrane filtration provides a new method for high throughput sample prep. The ultrafiltration-based filter plate is designed for automation-compatible sample purification, concentration and desalting of biological solutions, as well as protein removal from samples prior to instrument analysis. MultiScreen microplates are designed for low protein binding and high protein retention. The assay-grade plates meet stringent manufacturing release specifications and are lot tested for protein retention for >95% retention of cytochrome c (12,500 Daltons). They also offer high well-to-well uniformity on performance. These 96-well MultiScreen filter plate incorporates Ultracel® 10 membranes which are composed of 10,000 kDa nominal molecular weight limit regenerated cellulose ultrafiltration membrane for low-binding, high recovery results. Filtering microplates are designed for centrifugation and allow for processing and collection of sample volumes from 50 to 500µL. They are compatible with a range of standard receiver 96-well microtiter plates including 300µL, 700µL deep well and 150µL conical well microplate formats.