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Nalgene® media bottle closures are manufactured senatural HDPE screw closure with a GPI neck finish. Screw cap closures are specially designed for use with Nalgene® PET/PETG square media bottles to provide a leakproof seal. Gamma irradiated to provide 10-6 sterility assurance level (SAL). These media bottle screw cap closures meet current biological testing standards including USP Class VI, USP <661>, and European Pharmacopeia for Abnormal Toxicity (modified). It is non-cytotoxic, non-hemolytic, and non-pyrogenic. Made from ADCF (Animal Derived Component Free) material. Media bottle closures are available in both closed top and septum top screw cap styles.